CTPark Prešov North holds a strategic position in Prešov, the third-largest city in Slovakia. The Prešov Region benefits from extensive transporation connection throughout whole Slovakia and it is well-positioned for crossborder cooperation and trade with Poland, which is located only 70 km from the city of Prešov. Two technical universities in the area ensure access to a talented pool of skilled workers. The abundance of qualified workforce, combined with the park's strategic position, makes the park an ideal choice for companies engaged in logistics and high-tech production.

The park benefits from easy access to Slovakia's main west-east highway D1, connecting Prešov with Košice, Žilina, Martin, Trnava and Bratislava. Notably, the region benefits from ongoing road infrastructure development, including the recent opening of a 4.3 km R4 bypass in September 2023, with construction underway for an additional 10.2 km of roadway expected to be completed by 2027. Prešov is well-served by transportation infrastructure, with a railway running through the city and a bus transportation. The area also benefits from two international airports: Košice International Airport, (40 km) and Poprad-Tatry Airport (85 km).